METHODS Cefsulodin was prepared, taking phenylacetic acid as the starting material, followed by sulfonation, resolution, acylation, amidation and substitution, in 5 steps totally.

• 方法以苯乙酸为原料，经磺化、拆分、酰化、酰胺化和取代五步反应合成头孢磺啶。