METHODS 2-picolinic acid was used as start material,through chlorination,amidation,condensation sorafenib tosylate were sythesed.RESULTS and CONCLUSION Srafenib tosylate was synthesed in high yield.
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释义
方法以吡啶甲酸为原料,经过氯化,酰胺化,缩和并成盐制备获得对甲基苯磺酸索拉非尼。
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