Low dose of thrombin preconditioning can attenuate the toxic effect induced by high dose of thrombin.Its acting mechanism is associated with MAPK signal transduction pathway and HSP expression, etc.

• 小剂量凝血酶预处理可减轻大剂量凝血酶对神经细胞的毒性作用,其作用机制与MAPK信号转导途径、HSP表达等有关。