L-asparaginase is one of important medicines that cure acute lymphoblastic leukemia,but it s adverse effects have limited the enzyme widely use in clinic.

• 天门冬酰胺酶是儿童急性淋巴细胞白血病诱导治疗中不可缺少的重要药物,但其毒副作用限制了该酶的临床应用。