Keywords naproxen sodium;pseudoephedrine hydrochloride;sustained-release pellets;extrusion-spheronization;fluid-bed coating;central composite design;pharmacokinetics;

• 萘普生钠;盐酸伪麻黄碱;缓释微丸;挤出-滚圆法;流化床包衣;中心复合设计;药物动力学;