Keywords bioactivity valence;autocorrelation topological index;substituted aromatic compound;Photobacterium phosphoreum;Daphnia magnastraus;Pimephales promelas;acute toxicity.;

• 生物点价;自相关拓扑指数;取代芳烃、发光菌、大型蚤、呆鲦鱼、急性毒性.；;