Just getting this far required using single particle electron cryomicroscopy (cryo-EM) to produce three dimensional density maps of the molecule at sub-nanometer resolution.

• 为了看得更清楚起见，我们需要运用用于原生颗粒的冷蚀刻电子显微镜来观察在亚纳米分辨率下产生的三维分子图像。