It was found that in the D galactose induced aging mice the Akt/PKB, CREB and Bcl 2 is as well as PP 1 positive neurons decreased obviously, but AIF and Bax increased significantly.

• 结果 :D组小鼠海马神经元中Akt/PKB(蛋白激酶B)、CREB(cAMPresponseelementbindingprotein)和Bcl 2的免疫组化阳性细胞数明显减少 ,而AIF(凋亡诱导因子 )和Bax明显增加 ,PP 1 (蛋白磷酸酯酶 1 )也明显减少。