It suggested that TLR-4 may play a role in enhancing local host defence and inflammation via upregulating the expression of iNOS mRNA and the subsequent increased production of NO.

• :鼻黏膜上皮细胞通过TLR 4识别病原微生物 ,上调iNOSmrna的表达 ,增加NO的合成 ,以杀伤、清除病原菌 ,增强宿主防御和免疫应答。