It may be related to the histamine stimulated H_2-receptor of presymaptor of adrenergic fiber, and therefore it inhibited the release of monoamine transmitter.

• 实验还观察到:休克晚期NE、DA、5-HT的水平显著下降,而组胺则升高,这可能与组胺激活了肾上腺素能神经突触前膜的H_2受体,抑制了单胺类递质的释放有关。