It is discovered that fine particles and narrow distribution can be ob-tained in combination of static mixer and stirred tank reactor,also the crystal size can be controlled easily.

• 加料位置对粒径分布比较敏感，桨叶底部为较合适的加料位置。采用组合反应器，不但使颗粒粒径减小，而且使颗粒分布变窄。