It has been reported that MMP-2 and MMP-9 are activated after onset of stroke in clinical practice as well as in experimental brain ischemia and inhibiting the activityof MMP-9 can reduce brain infarct.

• 临床上已有报道MMP-2及MMP-9的活性在脑中风发作后明显升高。 动物实验也显示局部脑缺血后MMP-9在早期就被激活，抑制MMP-9的活性可以减小脑梗塞面积。