It has been identified that filaggrin gene is a susceptibility gene for AD, and the defect and loss of filaggrin protein may be a major cause of xerotic skin diseases.

• 中间丝蛋白基因突变是特应性皮炎发病的重要易患因素之一，中间丝蛋白的减少和缺失, 可能是引起特应性皮炎等干燥性皮肤病的主要原因。