Intrathecal injection of eNOS antisense oligonucleotides inhibited the expression of NMDA1AR mRNA in the spinal cord of morphine-withdrawal rats, but did not in the brainstem.

• eNOS反义寡核苷酸也可抑制吗啡戒断大鼠脊髓NMDA1AR mRNA表达的增加, 但作用弱于nNOS反义寡核苷酸, 对脑干NMDA1AR mRNA表达无明显影响。