Intra- and peri-articular responses such as toxicity, inflammation, bone loss, and prosthesis loosening caused by wear debris have been attributed to the failure of implants.

• 而这些颗粒会造成周围细胞或组织之毒性反应、发炎反应、骨吸收或是关节松脱等，并造成人工关节的失败。