Inhibition of protein secretion could lead to the growth decline,morphological alteration,and reduction of bacterial virulence,as well as the deprivation of their drug resistant.

• 为了克服细菌的抗药性问题,需要用新的思路去发掘新的抗生素,包括发掘细菌细胞中存在的抗生素作用的新靶点。