Increased dosage of maprotiline will enhance the concentration of drug,while the clinical effects may not be improved.

• 结论:在老年抑郁症患者中,麦普替林、去甲麦普替林及活性部分血药浓度存在个体差异,增加麦普替林日剂量会提高血药浓度,但不一定会增加疗效;