In this study, we reported that both growing culture and resting cells can transform nicotinic acid to 6-hydroxynicotinic acid, then in these two periods, we can both get the products.

• 本研究提出了双催化的方法，包括了发酵转化过程和静息细胞转化过程，突破了两步转化方法的局限，极大地提高了产物的得率，为工业化大规模生产6-羟基烟酸开辟了新的发展空间。