In this study, a novel chemical method was used to prepare the precursor dipeptide Gly-Asp diamide of RGD at large scale with low cost.

• 因此本文根据 RGD 的化学结构特点,采用化学- 酶法相结合的RGD 合成策略:先用新颖的化学法得到产量较高的前体GD 二肽酰胺,这一步反应操作简单，而且成本低廉；