In the precent studies,therefore,a series of experimental animal models are designed to investigate the effects of SIN on the opioid withdrawal syndrome and its primary mechanism.

• 本文通过建立大鼠、小鼠吗啡身体依赖模型及豚鼠回肠身体依赖模型，从整体和离体水平研究了青藤碱对阿片类戒断综合症的抑制作用，并初步探讨了其机制。