In order to search for bone? targeted leading compounds with high affinity and low toxicity, seven steroid? bisphosphonate compounds were synthesized.

• 本文设计合成了7个甾体?膦酸酯偶合物，希望新化合物既有趋骨性又有协同抗骨质疏松作用，能得到疗效好副作用小的骨靶向化合物的先导物。