In contrast, the releasing BDP of BDP-PLGA nano-capsules in vivo complied with double-room kinetics: there was relatively rapid blast-releasing at 0.5-1.0 hour, peaked at about 8 hours, followed by a high plateau up to 72 hours.

• 5一1 .；0小时有一个相对的“爆破”释放，8小时左右达峰浓度，12小时开始BDP浓度明显高于普通制剂组，并维持相当高浓度的平台期至72小时。