In contrast to subjects with early-onset depression (EOD), LOD is characterized by the coexistence of mood disorder and cognitive impairment.

• 本疾患遗传因素不如中青年患者明显,临床突出表现为情绪障碍与认知损害(执行功能障碍为主)并存,且多伴有脑血管病变或血管危险因素,国外研究认为其发病机制与中青年患者有所不同。