In conclusion, thrombin can induce GEC proliferation and GEC detachment. The latter is pro bably related to PA mediated over degradation of extracellular matrices such as fibronectin, which are needed for cell attachment.

• 结论：凝血酶可导致GEC增殖、脱壁，后者可被抑肽酶阻断，因而很可能与细胞贴壁所必需的FN等细胞外基质被升高的PA活性过度降解有关。