In amyotrophic lateral sclerosis (ALS), the progressive loss of upper and lower motor neurons leads to respiratory failure, often with predominant diaphragm dysfunction, and death.

• 目的：在肌萎缩性侧索硬化（ALS）中，上下运动神经元的进行性丧失导致呼吸衰竭，常伴有明显的膈肌功能紊乱和死亡。