In alkali catalytic condition, PBTCA (2-phosphono-1,2,4-tricarboxylic acid butane) is prepared from dialkyl-phosphite ester, maleic acid dialkylester and alkylacrylic easter by one-step successive reaction, its yield is 87.7%.

• 以二烷基亚磷酸酯、顺丁烯二酸二烷酯；以及丙烯酸烷酯等为原料；在强碱性催化条件下；经 一步连续反应合成PBTCA(2|膦酸基|1；2；4三羧酸丁烷)；产率为87.；7%25；