In addition, the upregulation of N-RAP expression in MLP (muscle LIM protein) knockout as well as in TOT mouse (tropomodulin overexpressing transgenic mouse) might serve as an early marker for the development of DCM (dilated cardiomyopathy).

• 它在MLP(muscle LIM protein，MLP)敲除和tropomodulin转基因小鼠中的表达都上调，提示有可能作为扩张型心肌病(dilated cardiomyopathy，DCM)的早期标志。