In addition, regardless of increased actiity in the pituitary gland, mice without SHP produce more testosterone prematurely, leading to premature maturation of primary sexual characteristics.

• 此外，不考虑脑垂体分泌活动的增加，没有SHP的小鼠也可以过早的产生更多的睾丸素，从而导致第一性征提前出现。