In DM group mice,renal glomerulus area was magnified,mesenterium basilaris substantia was increased,urinary cast lumina was enlarged,its vessel wall was thinner,GBM was thickening and obvious protein casts were observed compared with those of C group.

• DM组小鼠肾小球面积较C组增大,系膜基质增加、肾小管管腔扩大、管壁变薄、肾小球基底膜(GBM)增厚、蛋白管型明显。