In AD brain, the activity of choline acetyltransferase (acetyl CoA: choline O-acetyltransferase, EC 2.3.1.6, ChAT) and the level of neurotransmitter acetylcholine (ACh) obviously reduced.

• AD患者胆碱能神经细胞明显丢失；胆碱能神经纤维发生退变；导致中枢胆碱能系统功能紊乱；皮层、基底前脑的胆碱乙酰化转移酶(acetylCoA:choline-O-acetyltransferase；EC2.；3