In 1996,Ohta et al. identified a candidate tumor suppressor gene FHIT at 3p14.2 by exon trapping experiment. FHIT is classified into the gene family HIT(histidine triad),and as the first common fragile gene to be found,it is easy to rupture.

• FHIT基因是1996年Ohta等以外显子捕获法(exon trapping experiment)在3p14.；2区域定位的一个基因，属于组氨酸三联体(histidine triad，HIT)基因家族，因易于断裂，故命名为脆性三联组氨酸基因(FHIT)，覆盖FRA3B脆性位点。