If a lot of AHFS and CCO , MD decotion had been taken in long time,the renal function and histology would be injury.

• 药典法定剂量下单用细辛、威灵仙、北豆根水煎剂对大鼠肾脏无明显损害,但长期大剂量单用细辛、威灵仙、北豆根水煎剂则可引起肾脏组织形态及肾功能的改变。