IL 4 and IL 10 regulate CXCR4 expression on CD4 + T lymphocytes via both cAMP and cGMP signaling pathways. The capacity of IL 4 and IL 10 to regulate CXCR4 on CD4 + T lymphocytes was not linked to calcium mobilization stimulation.

• IL 4和IL 10通过环腺苷酸和环鸟苷酸双重信号途径对CD4+T细胞上CXCR4表达的调控与Ca2 +激活刺激无关。