However, one certain CpG motif is not always optimal to all host, so it is very important to screen CpG ODN with strong immunostimulatory activity on canine in vitro.

• 国外已经有关于人和小鼠的最佳基序的研究报道，国内关于CpG的基础性研究尚少，且未见有关犬的最佳CpG基序的研究报道。