However, because of the limitation of research methods, previous knowledge on the physiological and pathological significance of AK auto Ab is rather limited, and mechanism of production of AK auto Ab is unclear.

• 然而，由于实验方法等方面的局限性，以往对于AK auto Ab生理、病理意义的认识仍较为有限，而且以往常规的方法无法进行AK auto Ab产生机制等关键问题的研究。