Homology searches with the deduced 1695 amino acid protein sequence revealed human N-RAP shares 88% similarity with murine N-RAP, 90% with rat N-RAP, 63% with human Nebulin, 58% with rat Nebulin, 60% with chick Nebulin and 59% with murine Nebulin.

• 小鼠(NP 032759)和大鼠N-RAP蛋白(XP 217637)以及人(NP 004534)、小鼠(AAC52678)、大鼠(XP 229925)和鸡Nebulin蛋白(BAB18734)与人N-RAP一样，均含有多个串联重复的nebulin相关重复序列，相似的序列和结构域组成提示它们同属Nebulin家族。