His major systemic findings include cleft lip and palate, polydactyly, simian crease, congenital heart disease (V.S.D.), inguinal hernia, hypotonicity of neck and low set ear.

• 包括兔唇、腭裂、多指、断掌，心室中隔缺损，鼠蹊部疝气，颈部肌张力异常以及低位耳。