High expression of acrA gene leads to multiple-antbiotic-resistance in clinical isolates of Shigella,and Mar operon may contribute to the regulation of acrAB-tolC gene expression.

• 主动外排系统acrA基因高表达导致临床分离志贺菌产生多重耐药性; acrAB-tolC的表达可能受多种耐药操纵子调控。