Here we show that 27-hydroxycholesterol (27HC), an abundant cholesterol metabolite that is elevated with hypercholesterolemia and found in atherosclerotic lesions, is a competitive antagonist of estrogen receptor action in the vasculature.

• 在此我们发现27-羟基胆甾醇(27HC)是一种含量丰富的胆固醇代谢产物，它的过量引起高胆固醇血症并存于粥样硬化病变中，在血管中是雌激素受体竞争性拮抗剂。