Hepatic ischemia reperfusion leads to oxygen free radical producing excessively, calcium overload and ATP depletion, which destroy bile canalicular F-actin directly or indirectly. 4.

• 3．肝脏缺血再灌注造成氧自由基过量生成，细胞钙超载，ATP耗竭，直接或间接破坏胆小管F-actin微丝。