Hemin administration which induced oxidative stress could markedly elevate HO-1 level and cGMP concentration in platelet, while suppress ADP induced platelet aggregation in wild type mice.

• 同时,连续3d的氧化血红素注射,可使Wt小鼠血小板中HO-1的蛋白表达提高约4倍; 腺苷二磷酸(ADP)诱导的血小板聚集在Wt小鼠中出现显著降低;