HR can repair the DNA double strand breaks (DSBs) which is the most severe damage of DNA. It is not known whether Hp induce the occurrence of GCa by inhibiting the functions of BER genes and HR genes?

• HR是真核细胞修复DNA双链断裂(DNA double strand breaks, DSBs)的一个重要途径, HR相关基因的缺陷可引起DSBs修复减少,肿瘤发生率显著增加。