HPLC method with fluorescence detection for determination of dextromethorphan (1) and its active metabolite, dextrorphan (2) in human plasma was presented.

• 建立了简便、准确、灵敏的反相高效液相色谱-荧光检测法测定人血浆中右美沙芬和活性代谢物去甲右美沙芬的血药浓度。