HBV DNA level extremly decreased after Luminvudine therapy. The appearance of HBV YMDD mutants also connected with HBV genotypes,and 80%(4/5) of them accompanied by BCP double mutations.

• 口服拉米夫定可以明显降低HBV水平 ,HBVYMDD突变株的发生也与基因型有关 ,且 80%25 (4 5 )伴有BCP双突变