Guided by the nuclear localization sequence, almost all PAI-2 mutants entered nuclei, while wide type PAI-2 distributed evenly in the cytoplasm and nucleus.

• 结果提示在核定位序列的引导下，几乎所有的PAI-2都进入了细胞核，而野生型PAI-2则弥散分布于HeLa细胞内。