Generalized pustular psoriasis-like lesion and cerebral palsy of this boy have improved after the supplementation of biotin, but he may be remained wheelchair-dependent because of delayed diagnosis.

• 该患儿以脓疱性银屑病样损害及肌张力不全型脑性瘫痪为主要表现,生物素补充治疗疗效显著,但由于发现过晚,遗留下肢痉挛性瘫痪。