Gene therapy with IL-12 against tumor may increase the concentration of IL-12 in local tumor to increase effect and reduce the concentration in system to abate toxic effects.

• 经实验研究得到如下结果：AdcmvIL-12基因治疗Lewis肺癌效果较好本研究中全量IL-12组选用7×108pfu的剂量，半量IL-12组为3.；5×108pfu。