GRP78 in the Grp78 heterozygous mice substantially reduces the tumor microvessel density, it has no effect on vasculature of normal organs.

• 我们的研究结果发现了Grp78介导的三种主要机制：促进肿瘤细胞增殖、保护细胞免于凋亡、促进肿瘤血管发生。