From 4S in 1994 to IDEAL in 2005, 11 years of lots of randomized controlled clinical trials revealed plenitudinous evidence of the effectiveness and safety of lipid lowering with statins.

• 围绕着这个问题,开展了大量的大样本随机对照试验。从4S到IDEAL等他汀类药物的大规模随机对照临床试验研究中,可以看到他汀类降脂治疗在冠心病二级预防中的循证历程。