Four 3 thiomethylcephem intermediates were synthesized facilely from GCLE, by means of uniform design and HPLC tracing of reactions to give high yields of products.
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释义
以从青霉素化学转化得到的GCLE为原料,进行C-3位硫甲基官能化合成头孢菌素中间体。摸索了反应的条件,操作简单,收率高。
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